Diazo reaction, coupling reaction and condensation reaction are three common reactions in chemical processing, and they are also typical examples of exothermic reactions, the heat of which should be released in a timely manner. High temperature not only can cause nitrous acid decomposition, but also accelerate the decomposition of chemical compounds. The optimal temperature for reaction ranges between 0℃ and 10℃.
To provide the most ideal reaction temperature for production process in industries of biopharmaceuticals, chemical pharmaceuticals, pharmaceutical intermediates and pharma fine chemicals, a significant amount of ice can be used as a cooling agent to hold the reaction temperature in an appropriate range, thus guaranteeing the quality of products.
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